Wine is an alcoholic beverage made with the fermented juice of grapes. Technically, wine can be made with any fruit (i.e. apples, cranberries, plums, etc) but most wines are made with wine grapes (which are different than table grapes). Speaking of differences, the difference between wine and beer is that beer is made from fermenting brewed grains. So very simply, wine is made from fruit and beer is made from grains.